Prevention of amputation and rehabilitation for salvage of limbs attempts the retention of limb function in patients with diabetic, peripheral vascular, traumatic, or infectious conditions. Intervention involves wound management, therapeutic exercises, walking training, and orthotic devices. Multidisciplinary effort with physiatrists, surgeons, podiatrists, and therapists provides timely intervention. Evidence-based practice increases tissue viability, restores function, improves quality of life in patients, and reduces the risk of amputation.