Pain is one of the most common and debilitating conditions addressed in Physical Medicine. This session will focus on the integration of advanced pain management therapies with physical rehabilitation techniques to help patients regain function and improve daily living. The discussion will highlight non-invasive and minimally invasive strategies, including therapeutic exercise, ultrasound, manual therapy, electrotherapy, and cognitive-behavioral approaches. Experts will present case-based examples of managing musculoskeletal pain, neuropathic pain, and chronic post-surgical pain. Emphasis will be placed on reducing opioid dependency by promoting multimodal pain relief and functional restoration. The session will also examine how lifestyle modifications, ergonomics, and patient education contribute to sustainable pain management. Participants will learn about recent innovations in neurostimulation, regenerative therapies, and the use of biologics in treating musculoskeletal disorders. Discussions will extend to emerging technologies such as wearable sensors that track patient progress and AI-driven tools that personalize treatment. By attending, delegates will gain evidence-based strategies to address complex pain conditions through physical medicine. The session aims to empower healthcare professionals with approaches that not only relieve pain but also restore movement, enhance participation in daily activities, and significantly improve quality of life.